Education

1. Academic Background

BS    1982.09 – 1986.07   Zhejiang Medical University   

MS    1991.09 – 1994.12   Zhejiang Medical University   

Ph.D.  2004.01 – 2008.04   Zhejiang University        

2. Professional Experiences and Affiliations

1992.08 – 1996.12,Lecture,Zhejiang Medical University,China.

1997.01 – 1998.12,Associate Professor, Zhejiang Medical University,China.   

1999.01 – 2003.12,Associate Professor, College of Pharmaceutical Sciences, Zhejiang University , China.

2000.10 – 2001.04,Visiting Scientist, Qifu Pharmaceutical University, Japan.

2004.01 – Now,Professor,College of Pharmaceutical Sciences, Zhejiang University, China.   

Research Interests

1．Molecular design and evaluation of nanocarriers materials.

2．Novel drug delivery system of molecular target.

3．Drug controlled release.

MAIN RESEACH ACHIEVEMENTS
Publishing more than 70 articles in SCI in a number of prestigious and international journals including Journal of Controlled Release, Biomaterials, Molecular Pharmaceutics;Obtaining 23projects of National 973 Program and 863 Program、National Natural Science Foundation of China、Natural Science Foundation of Zhejiang Province,5 items of “National Science and Technology Progress Award, China”、“Science and Technology Award of Zhejiang Province”, 25 China patentsand a USpatent;Found Pharmaceutical preparations engineering laboratory of Zhejiang Province in 2012.

REPRESENTATIVE PUBLICATIONS

Ying-wen Hu, Yong-zhong Du, Na Liu, Xuan Liu, Ting-ting Meng, Bo-lin Cheng, Jia-bei He, Jian You, Hong Yuan, Fu-Qiang Hu*. Selective Redox-responsive Drug Release in Tumor Cells Mediated by Chitosan Based Glycolipid-like Nanocarrier, Journal of Controlled Release 2015 (206): 91-100

Yigang Su, Yingwen Hu, Yongzhong Du, Xuan Huang, Jiabei He, Jian You, Hong Yuan,    Fu-Qiang Hu*.  Redox-responsive polymer drug conjugates based on doxorubicin and chitosan  oligosaccharide-g-stearic acid for cancer therapy.  Molecylar Pharmaceutics,   2015 (12): 1193–1202.

Jing-Jing Yao; Yong-Zhong Du; Hong Yuan; Jian You; Fu-Qiang Hu*. Efficient gene delivery system mediated by cis-aconitate-modified chitosan-g-stearic acid micelles. Int J Nanomed. 2014,9,2993-3003

Jing Miao, Yong-Zhong Du, Hong Yuan Xing  Guo Zhang, Fu-Qiang Hu*. Drug resistance reversal activity of anticancer drug loaded solid l

ipid nanoparticles in mutidrug resistant cancer cells. Colloids and Surfaces B: Biointerfaces. 2013, 110, 74-80

Fu-Qiang Hu, Wan-Wei Chen, Meng-Dan Zhao, Hong Yuan and Yong-Zhong Du*. Effective antitumor gene therapy by Polyethylenimine conjugated stearic acid-g-chitosan oligosaccharide micelles. Gene Ther. 2013, 20(6), 597-606.

Jing-Jing Yan, Yong-Zhong Du*, Feng-Ying Chen, Jian You, Hong Yuan, Fu-Qiang Hu*. Effect of proteins with different isoelectric point on the gene transfection efficiency mediated by stearic acid grafted chitosan oligosaccharide micelles. Mol Pharm. 2013, 10(7), 2568-2577.

Fu-Qiang Hu, Yin-Ying Zhang, Jian You, Hong Yuan, Yong-Zhong Du *. PH triggered doxorubicin delivery of PEGylated glucolipid conjugate micelles for tumor targeting therapy. Mol Pharm. 2012, 9, 2469-2478.

Hong Yuan*, Xin Bao, Yong-Zhong Du, Jian You, Fu-Qiang Hu*. Preparation and evaluation of SiO2-deposited stearic acid-g-chitosan nanoparticles for Doxorubicin delivery. Int J Nanomed. 2012, 7, 5119-5118.

Yi-Ting Xie, Yong-Zhong Du, Hong Yuan, Fu-Qiang Hu*. Brain targeting study of stearic acid grafted chitosan micelle drug delivery system. Int J Nanomed. 2012, 7, 3235-3244.

Men-Dan Zhao, Yan-Mei Sun, Guo-Fang Fu, Yong-Zhong Du, Feng-Ying Chen, Hong Yuan, Cai-Hong Zheng, Xin-Mei Zhang*, Fu-Qiang Hu*.  Gene Therapy of endometriosis introduced by Polymeric micelles with glycollipid-like structure. Biomaterials. 2012, 33(2), 634-643.

Yong-Zhong Du, Li-Li Cai, Jin Li, Meng-Dan Zhao, Feng-Ying Chen, Hong Yuan, Fu-Qiang Hu*. Receptor mediated gene delivery by folic acid modified stearic acid grafted chitosan micelles. Int J Nanomed, 2011, 6, 1559-1568.

Yang-Yan Xu, Yong-Zhong Du, Hong Yuan, Yang-Ping Niu and Fu-Qiang Hu*. Improved cytotoxicity and multidrug resistance reversal of chitosan based polymeric micelles encapsulating oxaliplatin. J Drug Target. 2011, 19(5), 344-353.

Yong-Zhong Du, Ping Lu, Hong Yuan, Jian-Ping Zhou* and Fu-Qiang Hu*.Quaternary complexes composed of plasmid DNAprotaminefish sperm DNAstearic acod grafted chitosan oligosaccharide micelles for gene delivery. Int J Biol Macromol, 2011, 48(1), 153-159.

Su-Ting Huang, Yong-Zhong Du, Hong Yuan, Xing-Guo Zhang, Jing Miao, Fu-De Cui*, Fu-Qiang Hu*. Synthesis and anti-HBV activity of acyclovir coupling to stearic acid grafted chitosan oligosaccharide micelle. Carbohyd Polym, 2011, 83, 1715-1722.

Qian Li, Yong-Zhong Du, Hong Yuan, Xing-Guo Zhang, Jing Miao, Fu-De Cui* and Fu-Qiang Hu*. Synthesis of lamivudyl stearate and antivirus activity of stearic acid-g-chitosan oligosaccharide polymeric micelles delivery system. Eur J Pharm Sci, 2010, 41(3-4), 498-507.

Yue-Yu Zhou, Yong-Zhong Du, Ling-Wang, Hong Yuan, Jian-Ping Zhou* and Fu-Qiang Hu*, Preparation and pharmacodynamics of stearic acid and poly (lactic-co-glycolic acid) grafted chitosan oligosaccharide micelles for 10-Hydroxycamptothecin. Int J Pharm. 2010, 393,143-151.

Foundations

1)  National Natural Science Foundation of China (2014.01-2017.12)  Design and Evaluation of Nano-delivery System Against Cancer Stem Cells by Chemotherapy.

2)  National Natural Science Foundation of China(2012.01-2015.12)Fundamental Research of Intracellular Environment Responsive Gene Release System for Tumor Gene Therapy.

3)  National Major Scientific Research Project（973 program）(2009.01-2013.12)   Biological safety studies on the improvement ofinsoluble drugs efficacythrough nanotechnology.

4)  National Natural Science Foundation of China(2009.01-2011.12)Cancer gene therapy research of glycolipid-likenon-viral carriers nucleus targeted drug delivery system.

5)  National Natural Science Foundation of China(2005.01-2007.12) Study of gene delivery system of novelpolymer micelles.

6)  National 863Program(2004.01-2006.12) Research of lymph targeted drug delivery technology and its new drug creation.

Main Awards

1）2014  First Prize of Science and Technology Progress Award, Zhejiang Province.

2）2009 Second Prize of Natural Science Award for institutions of high-level universities.

3）2007 Second prize of National Science and Technology Progress Award, China.

4）2007  Third Prize of Science and Technology Award, Zhejiang Province.
   

5）2006  First Prize of Science and Technology Progress Award, Shanghai.

PATENTS

1)  A PEGylated and Fatty acid grafted chitosan oligosaccharide, synthesis method and application for drug delivery system：US8466127B2./

2)  25 issued patents in China.

Pharmaceutical preparations engineering laboratory of Zhejiang province

1)  Generic technology research and service platform of pharmaceutical preparations.

2) Key technology research and service platform for pharmaceutical preparations.

3) Technological platform for new drug creation.

4) Transformation platform for industrialization technology.

5) Technological platform forresearch technology,service and consulting platform for related information technology.

Main honors

The first batch of high-level innovative talents of Zhejiang Province.
 

Social work

1. Vice chairman of the biological particles Professional Committee of Chinese Society of Particulogy.

2. The member of Committee of Pharmaceutics, Chinese Pharmaceutical Association

3. Review experts of national drug.

4. Drug prices review experts of National Development and Reform Commission.

5. Director of Zhejiang Pharmacological Society.

6. The member of Committee of Pharmaceutics, Zhejiang Province.