Education

1994-1997    Ph.D., Organic Synthesis Chemistry

                      Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China

1991-1994    M.S., Organometallic Chemistry, Lanzhou University, China

1987-1991   B.S., Organic Chemistry, Lanzhou University, China

Professional Experience

2014-present      Professor, College of Pharmaceutical Sciences, Zhejiang University

2005-2014   Professor, Shanghai Institute of Materia Medica

2001-2005       Staff Scientist, VivoQuest Inc.

2000-2001       Postdoc. Researcher, Harvard Medical School, Institute of Chemistry & Cell Biology

1998-2000       Postdoc. Researcher, Drug Discovery Program, Georgetown University Medical Center

1997-1998    Visiting Scholar, Lab. of Organic Chemistry, School of Agricultural Sciences,

Nagoya University, Japan

Research Interests

Medicinal Chemistry; Chemical Biology; Combinatorial Chemistry; Multi-component or Cascade Reaction and Diversity-oriented Synthesis;

Honors

2010      Chinese Pharmaceutical Association-Sanofi-Aventis Young Researcher Award

2011      CAS “Zhu Li Yue Hua” Outstanding Teacher Award

Recent Selected Publications:

More than 60scientific papers and 5 authorized patents

1. J. Sheng, B. Chao, H. Chen, and Y. Hu*, Synthesis of Chromeno[2,3-d]imidazol-9(1H)-ones via Tandem Reactions of 3-Iodochromones with Amidines Involving Copper-Catalyzed C–H Functionalization and C–O Bond Formation, Org. Lett., 2013, 15 (17), 4508–4511.(IF：6.142)
2. W. Xing, Y. Fu, Z. Shi, D. Lu, H. Zhang*, Y. Hu,* Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors, European Journal of Medicinal Chemistry, 2013, 63, 95-103. (IF：3.499)
3. M. Cheng, J. Yan, F. Hu, H. Chen and Y. Hu*，Palladium-catalyzed cascade reactions of 3-iodochromones with aryl iodides and norbornadiene leading to annulated xanthones，Chemical Science, 2013, 4 (1), 526 – 530. (IF：8.314)
4. L. Huang, Y. Liu, F. Xie and Y. Hu*, An Organic Molecule Modulated Chemoselective Cyclization of Alkynyl Nitriles Tethered to 2-Alkyl Substituted Chromones with Multireactive Sites, Org. Lett., 2012, 14(24), 6122-6125.(IF：6.142)
5. J. Yan, M. Cheng, F. Hu, and Y. Hu*，Direct Synthesis of Functional Azaxanthones by Using a Domino Three-Component Reaction, Org. Lett., 2012,  14 (12), 3206–3209. (IF：6.142)
6. B. Chao, S. Lin, Q. Ma, D. Lu, and Y. Hu*, Copper(I)-Mediated Cascade Reactions: An Efficient Approach to the Synthesis of Functionalized Benzofuro[3,2-d]pyrimidines, Org. Lett.,2012, 14 (9), 2398–2401. (IF：6.142)
7. B. Chao, X. Tong, W. Tang, D. Li, P. He, J. Garcia, L. Zeng, A. Gao, L. Yang, J. Li, F. Nan, M. Jacobs, R. Altmeyer, J. Zuo*,and Y. Hu*, Discovery and Optimization of 2,4-Diaminoquinazoline Derivatives as a New Class of Potent Dengue Virus Inhibitors, J. Med.Chem.,2012, 55(7), 3135-3143.(IF：5.614)
8. F. Xie, H. Zhao, D. Li, H. Chen, H. Quan, X. Shi, L. Lou*, andY. Hu*, Synthesis and Biological Evaluation of 2,4,5-Substituted Pyrimidines as a New Class of Tubulin Polymerization Inhibitors, J. Med.Chem. 2011, 54(9), 3200-3205. (IF：5.614)
9. J. Gong, F. Xie, H. Chen and Y. Hu*, An Efficient Approach to Functionalized Benzo[a]xanthones through Reactions of 2-Methyl-3-(1-alkynyl)chromones with Electron-Deficient Chromone-Fused Dienes,Org. Lett., 2010, 12 (17), 3848–3851.(IF：6.142)
10. L. Zhao, F. Xie, G. Cheng, Y. Hu*, A Base-Promoted Tandem Reaction of 3-(1-Alkynyl)chromones with 1,3-Dicarbonyl Compounds: An Efficient Approach to Functional Xanthones, Angew. Chem. Int. Ed.,2009, 48(35), 6520–6523.(IF：13.734)

Selected Research Supports.

1. “the Hundred Talent Project of the Chinese Academy of Sciences.”     Chinese Academy of Sciences Grant Period: 2006 – 2008
2. “Design and synthesis of novel pyridimines compounds and its mechanism study for anti-cancer activity” The Shanghai Commission of Science and Technology (06PJ14112) Grant Period: 2006-2008
3. “Discovery on novel anti-tumor pyrimidine lead compounds and its mechanism” National Natural Science Foundation of China (30873142) Grant Period: 2009-2011
4. “Study on the novel pyridazinones compounds as drug candidate against liver cancer” Major Projects in National Science and Technology  (No.2009ZX09103-069) Grant Period: 2009-2010
5. “Study on the novel anti-diabetic compounds from the natural product D8 as drug candiated”  Major Projects in National Science and Technology  (No.2012ZX09103101-062) Grant Period: 2012-2015
6. “Diversity-oriented synthesis of highly substituted chromones through a domino and muticomponent reaction” National Natural Science Foundation of China (21172232) Grant Period: 2012-2015
7. “National Science Fund for Distinguished Young Scholar” National Natural Science Foundation of China (81225022) Grant Period: 2013-2016
8. “Preclinical study on the novel pyridazinone compound YHHU-756” Major Projects in National Science and Technology  (No.2013ZX09102008) Grant Period: 2013-2015