Education and Professional Experiences

1. Education：1986 Zhejiang Medical University, Bachelor in Pharmacy, 1992 Zhejiang Medical University, Master in Pharmaceutical Analysis，2004  Zhejiang University, Ph.D. in Physiology.
2. Overseas Study and Research Experience：1998.9-1999.2  Gifu Pharmaceutical University, Japan, Visiting Scholar; 2007.01-2008.12  The University of Michigan, USA, Visiting Scholar.
3. Work Experience：1986.8-1998.8  Zhejiang Medical University, Assistant Teacher,Lecture, Associate Professor; 1998.9-Present  College of Pharmaceutical Sciences, Zhejiang University, Associate Professor, Professor.

Research Interests

Drug transport and metabolism; drug transporters and diseases; metabolic drug(food)-drug interactions; preclinical pharmacokinetics of innovative drug

Selected Publications

 1. Wang YQ, Sun DL, Song FF, Hu YJ, Smith DE, Jiang HD*. Expression and regulation of proton-coupled oligopeptide transporter PhT2 by LPS in macrophages and mouse spleen. Mol Pharm, 2014, 11(6):1880-8. 

2. Tu MJ^#, Li LP^#, Lei HM, Ma ZY, Chen ZJ, Sun SY, Xu SY, Zeng S, Jiang HD*. Involvement of Organic Cation Transporter1 and Cytochrome P450 3A4 in Retrorsine Induced Toxicity. Toxicology, 2014, 322C:34-42.

3. Li LP, Song FF, Tu MJ, Wang K, Zhao L, Wu XD, Zhou H, Xia ZL, Jiang HD*. In vitro interaction of clopidogrel and its hydrolysate with OCT1, OCT2 and OAT1. Int J Pharm, 2014, 465(1-2):5-10.

4. Li LP^#, Tu MJ^#, Yang X, Sun SY, Wu XD, Zhou H, Zeng S, Jiang HD*. The contribution of human OCT1, OCT3 and CYP3A4 to the nitidine chloride induced hepatocellular toxicity. Drug Metab Dispos, 2014, 42:1227-34.

5. Sun SY^#, Wang K^#, Lei HM, Li LP, Tu MJ, Zeng S, Zhou H*, Jiang HD*. Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine. Prog Neuropsychopharmacol Biol Psychiatry, 2014,49:1-6.

6. Wang K, Sun SY, Li LP, Tu MJ, Jiang HD*. Involvement of organic cation transporter 2 inhibition in potential mechanisms of antidepressant action. Prog Neuropsychopharmacol Biol Psychiatry, 2014,53: 90-8.

7. Tu MJ, Sun SY, Wang K, Peng XY, Wang RH, Zeng S, Zhou H*, Jiang HD*. Organic cation transporter 1 mediates the uptake of monocrotaline and plays a key role in its hepatotoxicity. Toxicology, 2013, 311(3):225-30.

8. Sun DL, Wang YQ, Tan FQ, Fang DB, Hu YJ, Smith DE, Jiang HD*. Functional and Molecular Expression of the Proton-Coupled Oligopeptide Transporters in Spleen and Macrophages from Mouse and Human. Mol Pharm, 2013,10(4):1409-16.

9. Sun DL, Tan FQ, Fang DB, Wang YQ, Zeng S, Jiang HD*. Expression of Proton-Coupled Oligopeptide Transporter (POTs) in Prostate of Mouse and Patients with Benign Prostatic Hyperplasia and Prostate Cancer. Prostate, 2013, 73(3): 287-95.

10. Chen ZJ, Dai YQ, Kong SS, Song FF, Li LP, Ye JF, Wang RW, Zeng S, Zhou H*, Jiang HD*. Luteolin is a rare substrate of human catechol-O-methyltransferase favoring a para-methylation. Mol Nutr Food Res, 2013, 57(5):877-85.

11. Pan H, Gu LQ, Sun SY, Chen ZJ, Zhou H, Zeng S, Jiang HD*. Metabolism of Bis(4-fluorobenzyl)2 trisulfide and its formation of hemoglobin adduct in rat erythrocytes. Drug Metab Dispos, 2013, 41(5):1082-93.

12. Chen ZJ, Chen M, Pan H, Sun SY, Li LP, Zeng S, and Jiang HD*. Role of Catechol-O-methyl transferase in the disposition of luteolin in rats. Drug Metab Dispos, 2011, 39 (4):667-74.