Experience

2/2009-now       

Professor, Vice dean, College of Pharmaceutical Science, Zhejiang University

9/2004-2/2009 

Professor, Director of Institute of Materia Medica, College of Pharmaceutical Science, Zhejiang University

3/2002-8/2004 

Senior Scientist, Project Leader, Torrey Pines Institute for Molecular Studies. San Diego, CA. Design, Parallel and Combinatorial Synthesis of Small Drug-like Compounds Libraries

2/2000-2/2002

Postdoctoral Fellow, Torrey Pines Institute for Molecular Studies. San Diego, CA

Mentor: Dr. Richard A. Houghten

Design and Synthesis Combinatorial Libraries of Heterocyclic Compounds on         Solid-Phase.                                              

3/1997-12/1999

Graduate Assistant, Zhejiang University, Zhejiang, China,

Adviser: Professor Yaozu Chen (Member of Chinese Academy)

Modification and Biological Evaluation of Nature Products: Synthesis and Biological Evalution of New Antitumor Agents of Podophyllotoxins                                    

7/1992-3/1997   

Ningbo Star Chemistry Research Institute, China.

Multi-step Organic Synthesis of Drug and Drug Intermediates 

7/1989-7/1992

Graduate Assistant, Hangzhou University, Zhejiang, China.

Adviser: Professor. Yongmin Zhang

Applications of Samarium and Organotitanium in Organic Synthesis

Education

Ph.D., Organic Chemistry, Zhejiang University, Zhejiang, China. 1999

M.S., Organic Chemistry, Hangzhou University, Zhejiang, China. 1992

B.S., Chemistry, Hangzhou University, Zhejiang, China. 1987                   

Awards

1997   Third Place Award for Progress of Science and Technology, Education Commission, China

1996    First Place Award for Progress of Science and Technology, Zhejiang Education Commission

Professional Organizations

American Chemical Society

American Peptide Society

Publications

1.Jiaan Shao, Wanwan Yu, Zhanying Shao,Yongping Yu*, A “one-pot” multicomponent approach to polysubstituted 4-aminopyridines, Chem. Commun., 2012, 48, 2785–2787

2.Zhanying Shao, Qinhai Pan, Jun Chen,Yongping Yu*, Guolin Zhang*, Synthesis of polysubstituted 5-aminopyrimidine-2(1H)-thiones from vinyl azides and thiourea, Tetrahedron, 2012, 68, 6565-6568

3.Fangli Qiu, Jianwei Wu, Yaohong Zhang, Miao Hu,Yongping Yu*,One-pot cascade approach to 1,3´-bipyrrole derivatives from trisubstituted olefins with tosylmethyl-isocyanide (TosMIC), Tetrahedron Lett., 2012, 53, 446-448

4.Jingfeng Ouyang, Jiaan Sha, Hongbin Zou,Yijia Lou, Yongping Yu*, Hepatic Differentiation of Rat Mesenchymal Stem Cells by a Small Molecule, ChemMedChem, 2012, 7, 1447-1452

5.Wentang Chen, Jiaan Shao, Zhi Li, Marc A. Giulianotti, Yongping Yu*, Synthesis of 2,3,4- trisubstituted pyrroles via a facile reaction of vinyl azides and tosylmethyl isocyanide, Can. J. Chem., 2012, 90, 214-221

6.Fangli Qiu, Jianwei Wu, Yaohong Zhang, Miao Hu, Feng Yu, Guolin Zhang,Yongping Yu*, A Novel Synthesis of Multisubstituted Pyrroles via Trisubstiuted Olefins and TosMIC Derivatives, Lett. Org. Chem., 2012, 9, 305-308

7.Li Wang, Shen Liu, Zhi Li,Yongping Yu*, Palladium-Catalyzed Direct Olefination of Urea Derivatives with n-Butyl Acrylate by C-H Bond Activation under Mild Reaction Conditions, Org. Lett., 2011, 13, 6137-6139

8.Miao Hu, Jianwei Wu, Yaohong Zhang, Fangli Qiu, Yongping Yu*, Synthesis of polysubstituted 5-aminopyrimidines from α-azidovinyl ketones and amidines, Tetrahedron, 2011, 67, 2676-2680

9.Lili Ou, Jiaan Shao, Guolin Zhang*,Yongping Yu*;Metal-free carbon–nitrogen bond-forming coupling reaction between arylboronic acids and organic azides, Tetrahedron Lett., 2011, 52, 1430-1431

10.Wenteng Chen, Zhi Li, Lili Ou, Marc A. Giulianotti, Richard A. Houghten,Yongping Yu*, Solid-phase synthesis of skeletally diverse benzofused sultams via palladium-catalyzed cyclization, Tetrahedron Lett., 2011, 52, 1456-1458

11.Hongbin Zou, Liang Zhang, Jingfeng Ouyang,Marc A. Giulianotti, Yongping Yu*, Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents, Eur. J. Med. Chem., 2011, 46, 5970-5977

12.Lili Ou, Zhanying Shao, Wenteng Chen, Marc A. Giulianotti, Richard A. Houghten,Yongping Yu*, Solid-Phase Synthesis of 2,3,5,6-Tetrahydro-1H-imidazo[1,2-a]benzo[d]-[1,3] diazepines via Pd(OAc)₂/Cu(OAc)₂-Cocatalyzed Cyclization, Synlett, 2011, 15, 2259-2261

13.Jue Zhou*, Fan Qu,Yongping Yu, Chemical and Ecological Evaluation of a Genuine Chinese Medicine:Atractylodes Macrocephala Koidz, Afr. J. Tradit. Complem., 2011, 8, 405-411

14.Lili Ou, Shuang Han, Wenbo Ding, Ping Jia, Bo Yang, Jose L. Medina-Franco, Marc A. Giulianotti, Jian-Zhong Chen,Yongping Yu*, Parallel synthesis of novel antitumor agents: 1,2,3-triazoles bearing biologically active sulfonamide moiety and their 3D-QSAR, Mol Divers., 2011, 15, 927-946

15.Lili Ou, Shuang Han, Wenbo Ding, Zhe Chen, Ziqi Ye, Hongyu Yang, Guolin Zhang, Yijia Lou, Jian-Zhong Chen,Yongping Yu*, Design, synthesis and 3D-QSAR study of cytotoxic flavonoid derivatives, Mol Divers., 2011, 15, 665-675

16.Wenteng Chen, Miao Hu, Jianwei Wu, Hongbin Zou*,Yongping Yu*, Domino Approach for the Synthesis of Pyrrolo[1,2-α]pyrazine from Vinyl Azides, Org. Lett., 2010, 12, 3863-3865

17.Ting Ma, Wenteng Chen, Guolin Zhang,Yongping Yu*, Synthesis and Antitumor Evaluation of a Novel Class of 4-Substituted-1,4-Dihydroisoquinolin- 3-ones, J. Comb. Chem., 2010, 12, 488-490

18.Jianwei Wu, Wenteng Chen, Miao Hu, Hongbin Zou, Yongping Yu*, Synthesis of polysubstituted 5-aminooxazoles from α-diazocarbonyl esters and α-isocyanoacetamides, Org. Lett., 2010, 12, 616-618.

19.Wei Ye, Wenbo Ding, Zhang Hu,Yongping Yu*, Hongbin Zou*, Reduction of nitrosobenzenes to azoarenes with SmI₂, J. Chem. Res., 2010,4, 214-215

20.Chao Yao, Yandong Zhang, Guolin Zhang, Wenteng Chen, Richard A. Houghten, Yongping Yu*, Traceless Approach for the Synthesis of 3,5-Disubstituted Thiohydantoins on Functionalized Ionic-Liquid Support, Synthetic Commun., 2010, 40, 717-724.

21.Jinwen Xie, Ting Ma, Ying Gu, Xuzhao Zhang, Xi Qiu, Lei Zhang, Rongzhen Xu, Yongping Yu*, Berbamine derivatives: A novel class of compounds for anti-leukemia activity, Eur. J. Med. Chem., 2009, 44, 3293-3298.

22.Yandong Zhang, Zhe Chen, Yijia Lou, Yongping Yu*, 2,3-Disubstituted 8-arylamino-3H-imidazo [4,5-g]quinazolines: a novel class of antitumor agents, Eur. J, Med. Chem., 2009, 44, 448-452.

23.Zhang Hu, Ting Ma, Zhe Chen, Ziqi Ye, Guolin Zhang, Yijia Lou, Yongping Yu*, Solid-phase synthesis and antitumor evaluation of 2,4-diamino-6-aryl-1,3,5-triazines, J. Com. Chem., 2009, 11, 267-273.

24.Yangmei Li, Yongping Yu*, Marc A. Giulianotti, Richard A. Houghten, One-pot high-throughput synthesis of β-turn cyclic peptidomimetics via “volatilizable” supports, J. Org. Chem., 2009, 5, 2183-2185.

25.Ping Jia, Xulin Wu, Yongping Yu*, Guolin Zhang*, An efficient one-pot synthesis of 5,9-cyclo-1,11-oxido-pregn-16-ene-3,20-dione from 9-bromo-11-hydroxypregna- 1,4,16- triene-3,20-dione by two annulation reactions, Steroids, 2009, 74, 229-232.

26.Jinwen Xie, Jing Sun, Guolin Zhang, Richard A. Houghten, Yongping Yu*, A Traceless Approach for the Solid-Phase Parallel Synthesis of Trisubstituted Oxindoles, J. Com. Chem., 2007, 9, 566-568.

27.Yandong Zhang, Chao Yao, Richard A. Houghten, Yongping Yu*, Solid-phase Synthesis of 4,8-Disubstituted-8,9-dihydropyrazino[2,3-g]quinazolin-7(6H)-ones, Biopolymer, 2008, 90, 439-443.

28.Yandong Zhang, Chuanlian Xu, Richard A. Houghten, Yongping Yu*, Scaffold Approach for Solid-Phase Synthesis of 2,3-Disubstituted 8-Arylamino-3H-imidazo [4,5-g]quinazolines, J. Com. Chem., 2007, 9, 9-11.

29.Yandong Zhang, Qiaosheng Zhou, Richard A. Houghten, Yongping Yu*, Solid-phase synthesis of 3-alkyl-8-arylamino-1H-imidazo [4,5-g] quinazolin-2(3H)-thiones and 3-alkyl-8- arylamino-1H-imidazo [4,5-g] quinazolin-2(3H)-ones, Tetrahedron Lett., 2007, 48, 7042-7045.

Reviews

1.Hoesl, C.E., Nefzi, A., Ostresh, J.M., Yongping Yu., Houghten, R.A.Mixture-based Combinatorial Libraries: From Peptides and Peptidomimetics to Small Molecule Acyclic and Heterocyclic Compounds (Review). Methods in Enzymology(Book). (B.A. Bunin, G. Morales, Eds.), Academic Press, Volume 369, Chapter 25. Page 496. 2003.

2.Nefzi, A., Ostresh, J.M., Yongping Yu., Houghten, R.A. Combinatorial Chemistry: Libraries from Libraries, the Art of the Diversity-Oriented Transformation of Resin-Bound Peptides and Chiral Polyamides to Low Molecular Weight Acyclic and Heterocyclic Compounds. Journal of Organic Chemistry. 2004, 69(11), 3603.

Patent

1.Yongping Yu, John M. Ostresh, Richard A. Houghten, 1,3,5-Trisubstitrted-1,3,5-Triazine-2,4,6-Trione Compounds And Libraries. U.S. Patent (Pub. No.: US 20030186320A1)

2.Richard A. Houghten, Yongping Yu, “Method of support-based chemical synthesis employing aqueous HF for removal of silica gel supports”.U.S. Patent (Pub. No.: US 20050261474)