Education
1991-1994 Ph.D. Institute of Materai Medica, ChineseAcademy of Sciences, Shanghai, PRC

Professional Experience
1999-present, Professor and Doctoral Advisor, College of Pharmaceutical Sciences, Zhejiang University, PRC
1994-1998, Associate Professor, Zhejiang Medical University, PRC
1995-1996, Postdoctoral Fellow, University of Alberta, Canada
1987, Visiting Scientist, Gifu Pharmaceutical University, Japan
1977-1987, Assistant Professor, College of Pharmacy, Zhejiang Medical University, PRC

Research Interests
Drugs Design, Synthesis and Structure-activity Relationships
Antineoplasm Agents
Therapy Drugs for Senile Diseases and Reproductive Health
New Synthetic Methodology for Heterocyclic Compounds

Recent Publications

[1]     Hu, C.; Dou, X.; Wu, Y.; Zhang, L.; Hu, Y.*, Design, synthesis and CoMFA studies of N1-amino acid substituted 2,4,5-triphenyl imidazoline derivatives as p53-MDM2 binding inhibitors. Bioorganic & medicinal chemistry, 2012, 20, (4), 1417-1424.

[2]     Li, X.; Huang, S.; Hu, Y.*, Diversity-oriented derivatization of BODIPY based on regioselective bromination. Organic & biomolecular chemistry, 2012, 10, (12), 2369-2372.

[3]     Li, X.; Qian, S.; Zheng, L.; Yang, B.; He, Q.; Hu, Y.*, A mechanism-based fluorescent probe for labeling O6-methylguanine-DNA methyltransferase in live cells. Organic & biomolecular chemistry, 2012, 10, (16), 3189-3191.

[4]     Wu, P.; Su, Y.; Liu, X.; Yang, B.; He, Q.; Hu, Y.*, Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinase alpha (PI3Kalpha) inhibitors. Bioorganic & medicinal chemistry, 2012, 20, (9), 2837-2844.

[5]     Wu, P.; Su, Y.; Liu, X.; Yan, J.;Ye, Y.; Zhang, L.; Xu, J.; Weng, S.; Li, Y.; Liu, T.; Dong, X.; Sun, M.; Yang, B.; He, Q.; Hu, Y.*, Discovery of novel morpholino–quinoxalines as PI3Kα inhibitors by pharmacophore-based screening, Med. Chem. Commun.,2012, 3, (6), 659-662.

 [6]     Wu, P.; Su, Y.; Guan, X.; Liu, X.; Zhang, J.; Dong, X.; Huang, W.; Hu, Y.*, Identification of novel piperazinylquinoxaline derivatives as potent phosphoinositide 3-kinase (PI3K) inhibitors. PloS one, 2012, 7, (8), e43171.

[7]     Wang, W.; Hu, Y.*, Small molecule agents targeting the p53-MDM2 pathway for cancer therapy. Medicinal research reviews, 2012, 32, (6), 1159-1196.

[8]     Wu, P.; Hu, Y.*, Small molecules targeting phosphoinositide 3-kinases, Med. Chem. Commun.,2012, 3, (11), 1337-1355.

Recent Projects
National Natural Science Foundation of China (2009–2011)
Design, Synthesis and Bio-evaluation of Novel 2,4,5-triphenylheterocycles as P53-MDM2 Binding Inhibitors.
National Science and Technology Major Project “Major New Drug Discovery” Special Program (2009–2010)
Preclinical evaluation of novel anti-Alzheimer compound BYYT-25
National Science and Technology Major Project “Major New Drug Discovery” Special Program (2009–2010)
Crucial technology of lead compound design and optimization
National Science and Technology Supporting Project (2008–2010)
Green preparation technology integration and demonstration of dexamethanone based steroid hormoner intermediates
Major Project of Zhejiang Province （2008-2011)
Preclinical study of novel anti-Alzheimer compound BYYT-25
National Natural Science Foundation of China (2006–2008)
Design, Synthesis and QSAR studies of indanone derivatives as AChE inhibitors

Personal Patents
1.      Galanthamine derivatives, process for preparing them and use thereof. ZL200610050351.9
2.      Process for preparing 2-cyclohexenone compands. ZL200610154543.4
3.      Sulfur-containly quihoxalinedioxide, method for proceducing and application. ZL200610154536.4
4.      Benzal indone and benzyl indone derivatives, and its preparing method. ZL200510050401.9
5.      Tetra substituted chalcone derivatives and preparing method and use. ZL200510060431.8

Honors

AsiaOutstanding Doctoral Thesis Advisor Award

Baosteel Education Award

Current Roles
Director, Research Center for Innovative Drug Discovery, Zhejiang University, PRC
Director, Pharmaceutical Chemistry Lab
Deputy director, ZJU-ENS Joint Laboratory of Medicinal Chemistry, College of Pharmaceutical Sciences, Zhejiang University

Books
Medicinal Chemistry  People’s Medical Publishing House 2007-8
Medicinal Chemistry 6^th  People’s Medical Publishing House 2007-8
Medicinal Chemistry 2^nd  Higher Education Press 2005-06
 

Afflictions
Executive member of the council, Zhejiang Pharmaceutical Association
Member, Pharmaceutical Chemistry Committee, Chinese Pharmaceutical Association
Chairman, Pharmaceutical Chemistry and Antibiotic Committee, Zhejiang Pharmaceutical Association
Executive member of the council, Pharmaceutical Education Research Association, Chinese Association of Higher Education of Medicine
Member of the council, Zhejiang Licensed Pharmacists Association
Deputy editor-in-chief, Chinese Journal of Modern Applied Pharmacy Magazine
Editorial member, Drug Discoveries & Therapeutics Magazine
Editorial member, Chinese Journal of Medicinal Chemistry Magazine
Editorial member, Journal of Zhejiang University(Medical Sciences)
Vice chairman, Zhejiang Technology & Service Platform of New Drug Innovation
Member of construction experts group, Zhejiang Provincial Chemical and Medical Raw Materials Base Zone