Research Interests

1. Molecular mechanisms of Cardio-cerebrovascular diseases and potential drugable targets for pharmaceutical intervention;

2. Imbalance between the cellular death signalings and endogenous survival pathways during neurodegeneration and regeneration;

3. Biomarker discovery in neurodegenerative diseases and neurologic disorders;

4. Neurotoxicology (Nanoparticles and Chemical Toxicology) 

Education

M.S. Cardiovascular Pharmacology, Department of Pharmacology, School of Medicine Soochow University, China

Ph.D. Neuropharmacology/Neuroscience, Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan 

Professional Experiences and Affiliations

1. Professor (Dec 2011 – present), Vice Director, Department of Pharmacology, College of Pharmaceutical Science, Zhejiang University, Hangzhou, Zhejiang, China

2. Associate Professor (July 2008 – Dec2011), Department of Pharmacology, College of Pharmaceutical Science, Zhejiang University, Hangzhou, Zhejiang, China

3. JSPS Research Fellow (April 2007 – June 2008), Graduate School of Pharmaceutical Sciences, Tohoku University, Japan

4. Assistant Professor/Lecturer (Aug 1993 – Oct 2003), Department of Pharmacology, School of Medicine Soochow University, China 

REPRESENTATIVE GRANTS

1. Projects of International Cooperation and Exchanges NSFC (81120108023, 2012-2016)

2. National Natural Science Foundations of China (91232705; 2013-2015)

3. National Natural Science Foundations of China (30973521;2010-2012)

4. Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China，(R2100281, 2011.1-2013.12)

5. The Science and Technology Planning Project of Zhejiang Province (2009C34021, 2009-2011) 

HONORS & AWARDS

2012, Second level of 151 Talent Project of Zhejiang Province.

2012,“Qianjiang Talent”

2011, “Chinese Pharmacological Society Servier Award for young workers in Pharmacology”. [Chinese Pharmacological Society ] 

REPRESENTATIVE PUBLICATIONS

More than 50 research articles or reviews, total impact fact over 160.

1. Tao RR, Huang JY, Shao XJ, Ye WF, Y Tian, Liao MH, Fukunaga K,  Lou  YJ, Han F*, Lu YM. Ischemic injury promotes Keap1 nitration and disturbance of antioxidative responses in endothelial cells: a potential vasoprotective effect of melatonin.J Pineal Res. 2013; 54(3):271-81.【Impact factor: 7.304】*Correspondence author

2. Han F*, Chen YX, Lu YM, Huang JY, Zhang GS, Tao RR,Ji YL, Liao MH, Fukunaga K, Qin ZH. Regulation of the ischemia-induced autophagy-lysosome processes by nitrosative stress in endothelial cells. J Pineal Res. 2011; 51:124-135.【Impact factor: 7.304】*Correspondence author

3. Huang JY, Lu YM, Wang H, Liu J, Liao MH, Hong LJ, Tao RR, Ahmed MM, LiuP, Liu SS, Fukunaga K, Du YZ^*, Han F^*. The effect of lipid nanoparticle PEGylation on neuroinflammatory response in mouse brain. Biomaterials. 2013【Impact factor: 7.604】*Correspondence author

4. Han F*, Tao RR, Zhang GS, Lu YM, Liu LL, Chen YX, Lou YJ, Fukunaga K, Hong ZH. Melatonin ameliorates ischemic-like injury-evoked nitrosative stress: Involvementof HtrA2/PED pathways in endothelial cells. J Pineal Res. 2011, 50:281-291. 【Impact factor: 7.304】*Correspondence author

4. Zhang GS, Tian Y, Huang JY, Tao RR, Liao MH, Lu YM, Ye WF, Wang R, Fukunaga K, Lou YJ, Han F*. The γ-Secretase Blocker DAPT Reduces the Permeability of the Blood-Brain Barrier by Decreasing the Ubiquitination and Degradation of Occludin During Permanent Brain Ischemia. CNS Neurosci Ther.2012;19(1):53-60.【Impact factor: 4.458】*Correspondence author