Education

08/2005   Ph. D. in Pharmaceutical Science, the University of Connecticut, Storrs, CT, USA.

07/1996   Ph. D. in Organic Chemistry, Shanghai Institute of Materia Medica (SIMM), the Chinese Academy of Science (CAS), Shanghai, China.

07/1993   M. Sc. in Organic Chemistry, SIMM, CAS, Shanghai, China.

07/1990   B. Sc. in Chemistry, Hangzhou University, Hangzhou, Zhejiang, China

Professional Experiences and Affiliations

09/2008-             :  

 Professor of medicinal chemistry, Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, P. R. China

08/2006-09/2008:   

Research Associate, Dept. of Pharmaceutical Sciences, University of Pittsburgh, USA

01/2004-08/2006: 

Research Assistant and Postdoctoral Fellow, College of Pharmacy, University of Houston, USA

07/2001-01/2004: 

Research Assistant, Institute of Material Science (IMS), University of Connecticut, USA

07/1998-06/2001: 

Visiting Scholar, Instituteof Material Science (IMS), University of Connecticut. USA

07/1996-07/1998: 

Assistant Professor, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, P. R. China.

09/1990-07/1996: 

Graduate Research Associate, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, P. R. China.

Research Interests:

Computer-aided drug design and virtual screening

Drug lead syntheses

Drug-receptor interactions by NMR

Structure Activity Relationships (SAR) and screening by NMR

Patent:

Xiang-Qun Xie, Jian-Zhong Chen, Yuxun Zhang. LIGANDS SPECIFIC FOR CANNABINOID RECEPTOR SUBTYPE 2. 2007, U.S. Provisional Patent Application USSN 60/984,461.

Xiang-Qun Xie, Jian-Zhong Chen, Yuxun Zhang. LIGANDS SPECIFIC FOR CANNABINOID RECEPTOR SUBTYPE 2. 2009, PCT WO2009/058377A1

Jian-Zhong Chen, Chao-Yi Jiang, Hao-Shu Wu, Qiao-Jun He, Bo Yang, Preparation and Usage of a new type of DPP IV inhibitor. 2012，China Patent Application：201210008855.X

Selected Publications

1.Chaoyi Jiang, Shuang Han, Tiegang Chen, Jianzhong Chen, 3D-QSAR and docking studies of arylmethylamine-based DPP IV inhibitors. Acta Pharmaceu. Sin. B, 2012, in press

2.Lili Ou, Shuang Han, Wenbo Ding, Zhe Chen, Ziqi Ye, Hongyu Yang, Goulin Zhang, Yijia Lou, Jian-Zhong Chen*, Yongping Yu*. Design, synthesis and 3D-QSAR study of cytotoxic flavonoid derivatives, Mol Divers (2011) 15:665–675.

3.Lili Ou, Shuang Han, Wenbo Ding, Ping Jia, Bo Yang, Jose L. Medina-Franco, Marc A. Giulianotti, Jian-Zhong Chen*, Yongping Yu*, Parallel synthesis of novel antitumor agents: 1,2,3-triazoles bearing biologically active sulfonamide moiety and their 3D-QSAR. Mol Divers, (2011), 15:927–946.

4.J.-Z. Chen, K.-Z. Myint, X.-Q. Xie, New QSAR prediction models derived from GPCR CB2-antagonistic triaryl bis-sulfone analogues by a combined molecular morphological and pharmacophoric approach. SAR and QSAR in Environmental Research. (2011), 22(5-6): 525–544.

5.Jurg Gertsch, Marco Leonti, Stefan Raduner, Ildiko Racz, Jian-Zhong Chen, Xiang-Qun Xie, Karl-Heinz Altmann, Meliha Karsak, and Andreas Zimmer, Beta-caryophyllene is a dietary cannabinoid. PNAS, (2008), 105: 9099-9014

6.Xiang-Qun Xie, Jian-Zhong Chen, Data-Mining Representative Small Molecule Drug Screening Database from NIH PubChem. J. Chem. Info. Modeling, (2008), 48: 465-475.

7.Shuli Mao, Donald Probst, Stefan Werner, Jian-Zhong Chen, Xiangqun Xie, and Kay M. Brummond Diverging Rh(I)-Catalyzed Carbocylization Strategy to Prepare a Library of Unique Cyclic Ethers. J. Comb. Chem., (2008), 10: 235-246.

8.Jian-Zhong Chen, Junmei Wang, Xiang-Qun Xie. GPCR Structure-Based Virtual Screening Approach for CB2 Antagonist Search. J. Chem. Info. Modeling, (2007), 47(4), 1626-1637.

9.Stefan Raduner, Adriana Majewska, Jian-Zhong Chen, Xiang-Qun Xie, Jacques Hamon, Bernard Faller, Karl-Heinz Altmann, Jürg Gertsch. Alkylamides from Echinacea are a new class of cannabinomimetics. CB2-RECEPTOR DEPENDENT AND INDEPENDENT IMMUNOMODULATORY EFFECTS. J. Biol. Chem. (2006), 281(20), 14192-14206.

10.Jian-Zhong Chen, Xiu-Wen Han, Qian Liu, Alexandros Makriyannis, Junmei Wang, and Xiang-Qun Xie. 3D QSAR Studies of Arylpyrazole Antagonists of CB1 and CB2 Cannabinoid Receptors. A Combined NMR and CoMFA Approach. J. Med. Chem. (2006), 49(2), 625-636.

11.Jian-Zhong Chen, Shrirang V. Ranade, Xiang-Qun Xie. NMR characterization of
paclitaxel/poly (styrene-isobutylene-styrene) formulations.Int. J. Pharmaceu., (2005), 305(1/2), 129-144

12.Xiang-Qun Xie, Jian-Zhong Chen. NMR structural comparison of the cytoplasmic
juxtamembrane domains of G-protein coupled CB1 and CB2 receptors in
membrane-mimetic DPC micelles.J. Biol. Chem. (2005), 280(5), 3605-3612.

13.Jian-Zhong Chen, Xiu-Wen Han, Xiang-Qun Xie. Preferred conformations of endogenous cannabinoid ligand anandamide. Life Sci., (2005), 76, 2053-2069

14.Haihu Qin, Brian J. Chakulski, Ingrid A. Rousseau, Jian-Zhong Chen, Xiang-Qun Xie, Patrick T. Mather, Gregory S. Constable, Bryan E. Coughlin.  Synthesis and characterization of unsaturated thermotropic polyesters prepared via acyclic diene metathesis polymerization.Macromolecules (2004), 37(14), 5239-5249. 

15.Xiang-Qun Xie, Jian-Zhong Chen, Eric M Billing. 3D structural model of the G-protein coupled cannabinoid CB2 receptor. Proteins (2003), 53, 307-319