Dr. Zhong Chen got his Ph.D in Okayama University, Japan, in 1999, and now is a professor in Zhejiang University, China. He was one of the Chinese National Distinguished Young Scientific Scholars and was considered as Distinguished Professor by Zhejiang University. His research interests mainly focus on two fields: 1) the roles of histamine and histamine receptors in ischemic cerebral injury and development of H3 antagonists; 2) Molecular mechanisms of epileptic pathogenesis and development of antiepileptic drugs.

During last five years, his research work has been funded by Key Project of National Natural Science Foundation, National Natural Science Foundation and key project of drug developing foundation in China. As a Co-PI, Dr. Chen participated in one NIHR01 project and one Chinese National Basic Research Program of China (973 projects). He has published over 100 papers including Nature Neurosci, J Neurosci, Mol Med, Epilepsia, Br J Pharmacol, ect. And he has gained several Chinese National Scientific award in the last five years.

As the Executive Dean of College of Pharmaceutical Science and the vice Dean of Medical School, Zhejiang University, he puts a lot of efforts in pushing forward the collaboration and exchange between Pharmaceutical Colleges in China and abroad.

EDUCATIONAL BACKGROUND

1999-1999   Postdoctoral Fellow, Okayama University, Japan

1996-1999   Ph.D, Okayama University, Japan

1994-1996   Master of Science, Okayama University, Japan

1986-1992   Bachelor of Science, Shanghai Medical University, China

PROFESSIONAL EXPERIENCES AND AFFILIATIONS

2009-Present  Executive vice Dean, College of Pharmaceutical Sciences, Vice Dean of Medical School, Zhejiang University, China

2005-2009    Vice Dean, Basic Medical College, Zhejiang University, China

2002-Present  Professor, Ph.D supervisor, Zhejiang University, China

2008       Advanced visiting and collaborative researcher for two months, University of Pennsylvania, USA.

2008        Advanced visiting and collaborative researcher for three months, University of Toronto, Canada

2002-2003    Visiting Professor, Tohoku University, Japan

1999-2002    Associate Professor, MS supervisor, Zhejiang University, China

1993-1994    Visiting Scholar, Okayama University, Japan

HONORS & AWARDS

2007   Distinguished Young Scholars of National Science Fund 

2011   Zhejiang University DistinguishedScholars;

2006  First Prize of Science and Technology Progress Award, Shanxi Province

2010  Second Prize of Science and Technology Progress Award, Zhejiang Province

2008  Second prize of National Science and Technology Progress Award, China

2008  Outstanding Returnee of Zhejiang Province in the last thirty years

2007  High-level innovative talents of Zhejiang Province

2007  Science and Technology Award for Youth of Zhejiang Province

2006  151 Talent Project of Zhejiang Province, Focal training level

2006  Second Prize of Science and Technology Progress Award, Zhejiang Province

2005  Second Prize of Science and Technology Progress Award, Zhejiang Province

2004  151 Talent Project of Zhejiang Province, First level

2002 Chinese Pharmacological Society-Servier Young Investigator Awards in Pharmacology

RESEARCH AREAS

• Neuropharmacology of brain histamine and histamine receptors
• Molecular mechanisms of onset and treatment of epilepsy, ischemic neuronal injury
• Development of antiepileptic drugs and drugs for neuropathic pain

GRANTS UNDERGOING

1. National Science Fund for Distinguished Young Scholars, neuropsychiatric pharmacology, No.30725047, 2 million RMB, 2007-2011, PI.

2. The Key Project of National Natural Science Foundation, protective effect and mechanism of histamine on brain ischemia and its relation with glial scar, No. 81030061, 2.4 million RMB, 2011-2014, PI.

3. NIHR01 funded project, Genetics and phenomics of wide spread neuropathic trigeminal pain in the mouse, No. 1R01DE018575-01, 192.3 thousand USD, 2007-2012, PI.

4. National significant project for new drug creation: technological platform for pre-clinical pharmacodynamic evaluation of new drugs for tumor, cardiovascular diseases and neuropsychiatric disorders, No. 2009ZX09303-004, 3.6 million RMB, 2009-2011, PI.

5. National Basic Research Program of China (973 project), roles of glias in repair and functional reconstruction after injury in the central nervous system, No. 2011CB504403, 1.6 million RMB, 2011-2015,  PI.

SELECTED PUBLICATIONS (* corresponding author)

1. Fan YY, Hu WW, Dai HB, Zhang JX, Zhang LY, He P, Shen Y, Ohtsu H, Wei EQ, Chen Z*. Activation of the central histaminergic system is involved in hypoxia-induced stroke tolerance in adult mice. J Cereb Blood Flow Metab. 2011;31(1):305-14. (IF=5.741)

2. Xu ZH, Wu DC, Fang Q, Zhong K, Wang S, Sun HL, Zhang SH, Chen Z*  Therapeutic time window of low frequency stimulation at entorhinal cortex for amygdaloid-kindling seizures in rats. Epilepsia. 2010;51(9):1861-9 (IF=4.02).

3. Shen Y,  He P,  Fan YY, Zhang  JX,  Yan HJ ,  Hu WW,  Ohtsu H,  Chen Z*. Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knock-out mice through reducing glutamate excitotoxicity. Free Radical Bio Med. 2010;48(5):727-35. (IF=6.02)

4. Wu DC, Zhu-Ge ZB, Yu CY, Fang Q, Wang S, Jin CL, Zhang SH, Chen Z*. Low-frequency stimulation of the tuberomammillary nucleus facilitates electrical amygdaloid-kindling acquisition in Sprague-Dawley rats. Neurobiol Dis. 2008;32(1):151-6. (IF=4.852)

5. Wu DC, Xu ZH, Wang S, Fang Q, Hu DQ, Li Q, Sun HL, Zhang SH, Chen Z*. Time-dependent effect of low-frequency stimulation on amygdaloid-kindling seizures in rats. Neurobiol Dis. 2008;31(1):74-9. (IF=4.852)

6. Wang S, Wu DC, Ding MP, Li Q, Zhuge ZB, Zhang SH, Chen Z*. Low-frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague-Dawley rats. Neurobiol Dis. 2008;29(1):52-8. (IF=4.852)

7. Shen Y, Hu WW, Fan YY, Dai HB, Fu QL, Wei EQ, Luo JH, Chen Z*.Carnosine protects against NMDA-induced neurotoxicity in differentiated rat PC12 cells through carnosine- histidine-histamine pathway and H(1)/H(3) receptors. Biochem Pharmacol. 2007; 73(5):709-17. (IF=4.838)

8. Liu L, Zhang S, Zhu Y, Fu Q, Zhu Y, Gong Y, Ohtsu H, Luo J, Wei E, Chen Z*. Improved learning and memory of contextual fear conditioning and hippocampal CA1 long-term potentiation in histidine decarboxylase knock-out mice. Hippocampus. 2007;17(8):634-41. (IF=5.75)

9. Dai HB, Zhang ZM, Zhu YP , Jin C L , Shen Y, Huang YW , Timmerman H, Zhang WP, Luo JH, Leurs R, Chen Z*. Histamine protects against NMDA-induced necrosis in cultured cortical neurons through H2 receptor/Cyclic AMP/protein kinase A and H3 receptor/GABA release pathways. J Neurochem. 2006;96:1390-400. (IF=4.5)

10. Chen Z*, Sakurai E, Hu WW, Jin CL, Kiso Y, Kato M, Watanabe T, Wei EQ, Yanai K. Pharmacological effects of carcinine on histaminergic neurons in the brain. Br J Pharmacol. 2004;143:573-80. (IF=4.902)

11. Zhong K, Wu DC, Jin MM, Xu ZH, Wang Y, Hou WW, Li XM, Zhang SH, Chen Z. Wide therapeutic time-window of low-frequency stimulation at the subiculum for temporal lobe epilepsy treatment in rats. Neurobiology of Disease 2012 Oct;48(1):20-6. [Epub ahead of print]

12. Li KX, Lu YM, Xu ZH, Zhang J, Zhu JM, Zhang JM, Cao SX, Chen XJ, Chen Z, Luo JH, Duan S, Li XM(2011) Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy. Nat Neurosci. 2011 Dec 11;15(2):267-73. [Epub ahead of print]113.

13.Dou Y, Wu HJ, Li HQ, Qin S, Wang YE, Li J, Lou HF, Chen Z, Li XM, Luo QM, Duan S. Microglial migration mediated by ATP-induced ATP release from lysosomes. Cell Res. 2012 Jun;22(6):1022-33.

14. Zhong WX, Wang YB, Peng L, Ge XZ, Zhang J, Liu SS, Zhang XN, Xu ZH, Chen Z, Luo JH. Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine beta-synthase: a target for neuronal antioxidant defense. J Biol Chem. 2012 Aug 13. [Epub ahead of print]

15.Gong N, Li Y, Cai GQ, Niu RF, Fang Q, Wu K, Chen Z, Lin LN, Xu L, Fei J, Xu TL（2009）GABA transporter-1 activity modulates hippocampal theta oscillation and theta burst stimulation-induced long-term potentiation. J Neurosci. 2009 Dec 16;29(50):15836-45.

BOOK EDITING

1. Editor, "Medical Scientific Research Methods" (editor, Kun Chen and Zhong Chen), Science Press, ISBN：978-7-03-03041-55;2010

2. Associate editor, "Journal of Clinical Pharmacology Tutorial" (editor, Er-Qing Wei), Science Press, ISBN 978-7-03-019870-9; 2007

3. Associate editor, "Biomedical on the English writing" (editor, Er-Qing Wei), Science Press, ISBN 7-03-017068-7; 2006

4. Editorial member of "Pharmacology experimental guidance" (editor, Yan-Jie Lü), People's Health Publishing House, ISBN 978-7-117-09987-5/R.9988; 2008

5. Participating editor, "Neuropsychiatric Pharmacology" (editor, Bao-Shan Ku), Beijing University Press, ISBN 7-81071-854-1/R.854; 2006.

6. Participating editor, "Endocrine and Immune Pharmacology" (editor, Bao-Shan Ku), Beijing University Press, ISBN 978-7-81116-203-5; 2008.

PATENT

Sheng Rong, Hu Yongzhou, Chen Zhong, Xu Lisha: Phenoxy indene ketone compounds and their preparation methods and using. ZL200410016180.9 (2006.04.19)

SOCIAL WORK

Chairperson of Zhejiang Pharmacological Society

Vice chairman of the Professional Committee of Neuropsychopharmacology of Chinese Pharmacological Society

Director of Chinese Pharmacological Society

Director of Chinese Association of Neuroscience

Vice director of Key Laboratory of Medical Neurobiology, Ministry of Health, China

Vice director of Zhejiang Key Laboratory of Neurobiology, China

Editor of Clinical Experimental Pharmacology and Physiology

Editor of Journal of Zhejiang University (Medical Sciences)