On February, Professor CHEN Zhong's lab published a research article entitled Dissecting the Role of Subiculum in Epilepsy: Research Update and Translational Potential in the top-tier research Progress in Neruobiology.

The subiculum serves as the strategic core output of the hippocampus, through which neural activity exits the hippocampal proper and targets the entorhinal cortex and other more distant subcortical and cortical areas. The past decade has witnessed a growing interest in the subiculum, owing to discoveries revealing its critical role in regulating many physiological and pathophysiological processes. Notably, accumulative evidence from both clinical and experimental studies suggests that the subiculum plays a vital role in seizure initiation and propagation, in epilepsy. In this review,  it briefly describe the structure and connectivity of the subiculum and then summarize the molecular and cellular mechanisms in the subiculum underlying the epileptic brain, in both epilepsy patients and animal models. Next, the lab review some translational approaches targeting the malfunctioned subiculum to treat epilepsy. Finally,  researchers open questions for future research in the subiculum and their clinical translation challenges.

This work was carried out by Ph.D. student FEI Fan under the supervision of Professor CHEN Zhong. 

全文链接：https://www.sciencedirect.com/science/article/pii/S0301008221000435?via%3Dihub